TitleImproved in vivo targeting of BCL-2 phenotypic conversion through hollow gold nanoshell delivery.
Publication TypeJournal Article
Year of Publication2019
AuthorsMorgan, E, Gamble, JT, Pearce, MC, Elson, DJ, Tanguay, RL, Kolluri, SKumar, Reich, Norbert O
JournalApoptosis
Date Published2019 Mar 16
ISSN1573-675X
Abstract

Although new cancer therapeutics are discovered at a rapid pace, lack of effective means of delivery and cancer chemoresistance thwart many of the promising therapeutics. We demonstrate a method that confronts both of these issues with the light-activated delivery of a Bcl-2 functional converting peptide, NuBCP-9, using hollow gold nanoshells. This approach has shown not only to increase the efficacy of the peptide 30-fold in vitro but also has shown to reduce paclitaxel resistant H460 lung xenograft tumor growth by 56.4%.

DOI10.1007/s10495-019-01531-1
Alternate JournalApoptosis
PubMed ID30879165
Grant ListR01 EB012637 / / National Institutes of Health /
5RO1ES016651 / / National Institutes of Health /
W81XWH-08-1-0600 / / Medical Research and Material Command /
W81XWH-12-1-0069 / / Medical Research and Material Command /
RSG-13-132-01-CDD / / American Cancer Society /